CEST Imaging
With CEST MRI, solutes with very low concentrations can be detected through the presence of exchangeable protons in groups. Thus CEST MRI is a technique that has a variety of applications.
Research
Development and Translation of D-glucose as a Diagnostic Agent for MRI of Cancer
Contrast agents are used to visualize tumor anatomy and physiology, which can provide information on malignancy and the response to treatment. Our hypothesis is that D-glucose as an infusible MRI contrast agent can provide information on three important aspects of tumor physiology, namely delivery, uptake (including effects of blood-brain barrier disruption), and metabolism. If our developments are successful, translation to clinical application will be fast since D-glucose is already widely used for other indications.
For a good overview of the theory with past and ongoing research, the Doctoral Thesis from our group by Dr. Anina Seidemo is recommended.
In addition, other CEST publications from our group can be found here
